Risk Factors for Acute Kidney Injury During Aminoglycoside Therapy

Risk factors include prior aminoglycoside therapy within the past 6 months, young age, and hematology/oncology admission.

Aminoglycosides are well known to be nephrotoxic. To determine whether prior aminoglycoside therapy is a risk factor for acute kidney injury (AKI) during current aminoglycoside therapy, researchers examined serum creatinine concentrations in a retrospective cohort of children (age range, 1 month to 18 years) who received aminoglycosides at a Canadian children's hospital from 2008 to 2012. Patients with prior renal disease or acute renal conditions were excluded.

The analysis included 683 aminoglycoside treatments. Of these, 317 were associated with at least one prior aminoglycoside treatment in the preceding 6 months. Stage 1, 2, or 3 AKI occurred during 284 treatments (42%). Prior aminoglycoside treatment was significantly associated with d…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Risk Factors for Acute Kidney Injury During Aminoglycoside Therapy

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Reviewing Author