Barrett Esophagus and Risks for Cancer Incidence, Mortality

A U.S. cohort analysis quantifies risks for esophageal adenocarcinoma, other forms of cancer, and other conditions.

The risk for incident esophageal adenocarcinoma (EAC) associated with Barrett esophagus (BE) was reported to range up to 2.5% in studies from tertiary referral centers. More recently, a study of U.S. veterans showed an annual risk of 0.32% (NEJM JW Gastroenterol March 2015 and Am J Gastroenterol 2014; 109:1862), and European cohort studies have also shown low risks; however, data on broader risks for cancer and other conditions, and related mortality, have been conflicting and subject to reporting bias. To shed further light, researchers performed a comprehensive analysis of data from a large U.S. health provider.

All adult patients who had 6 months of continual follow-up immediately after a diagnosis of BE between 1995 and 2012 were eligibl…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors