Interferon-Free Direct Antivirals for Hepatitis C Infection Post-Renal Transplant

Direct antiviral agents are highly effective even without ribavirin, but close monitoring of immunosuppressive therapy is necessary.

Recent data have shown that interferon-free direct antiviral agents (DAAs) are not only effective, but also safe for hepatitis C virus (HCV)-infected patients after kidney transplantation (NEJM JW Gastroenterol Feb 2017 and Ann Intern Med 2017; 166:109). It is thought that DAAs do not precipitate kidney rejection, which has been reported with interferon-based therapies. However, the safety of DAA regimens has been demonstrated only in small case series.

Now, investigators have conducted a large retrospective multicenter study of post-kidney transplant HCV patients who have undergone DAA-based regimens. Clinical and virologic data were collected as a part of a Spanish registry of 103 HCV patients undergoing DAA therapy following kidney transp…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Interferon-Free Direct Antivirals for Hepatitis C Infection Post-Renal Transplant

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Reviewing Author