Updated Guideline for Treating Patients with Helicobacter Pylori Infection

Bismuth-based quadruple therapy or concomitant therapy with a proton-pump inhibitor and three antibiotics is recommended as first-line therapy.

Sponsoring Organization: American College of Gastroenterology (ACG)

Target Audience: Gastroenterologists and primary care providers

Background and Objective

This updated, evidence-based guideline with graded recommendations incorporates advances in the field since the previous ACG guideline was published in 2007.

What's Changed

It has become clear that antibiotic resistance is a major determinant of eradication failure. New regimens are now proposed for both first-line and salvage therapies, and modifications of the drug doses and duration of therapy are addressed.

Key Recommendations

First-line treatments may include:
- Quadruple bismuth-based therapy for 10 to 14 days
- Concomitant (a proton-pump inhibitor plus three antibiotics) therapy for 10 to 14…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose