Antibiotic-Resistant Enterobacteriaceae in China: Epidemiological and Clinical Findings

The mcr-1 gene, which confers horizontally transferable colistin resistance, is widespread in human-origin Enterobacteriaceae in China.

The mcr-1 gene confers resistance to colistin, one of the last options for treating multidrug-resistant infections, and has recently been identified in bacteria of human and animal origin in multiple countries (NEJM Journal Watch Infect Dis Jan 2016 and Lancet Infect Dis 2016 Feb; 16:161). Now, investigators in two studies have assessed the prevalence and risk factors for mcr-1 in Enterobacteriaceae in human samples in China, where colistin is used in animals but not yet in humans.

Wang and colleagues conducted several analyses at two large tertiary care hospitals in different Chinese provinces. They retrospectively analyzed 17,498 isolates of Enterobacteriaceae, Acinetobacter spp., and Pseudomonas aeruginosa from inpatients. They detected m…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Antibiotic-Resistant Enterobacteriaceae in China: Epidemiological and Clinical Findings

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Reviewing Author