Autoimmune GFAP Astrocytopathy Associated with Meningitis, Encephalitis, and Myelitis

Clinical and radiologic correlations of a newly proposed clinical–pathological entity

Glial fibrillary acidic protein (GFAP) astrocytopathy is a newly proposed autoimmune neurologic syndrome characterized by meningitis, encephalitis, or myelitis associated with immunoglobulin G (IgG) antibodies to GFAP. Now, investigators describe clinical and radiologic characteristics in 102 patients with GFAP-IgG seropositivity.

Among 102 symptomatic GFAP-IgG serum- or cerebrospinal fluid (CSF)–positive patients (including 38 deeply phenotyped at the authors' home institution), median age at onset was 44 years old but ranged widely (8 to >100 years); 54% were women. The phenotype was meningitis, encephalitis, or myelitis in isolation or in combination in 81% of all patients with GFAP-IgG positivity in serum, CSF, or both and in 94% of CSF …

Reviewing Author

Jeffrey M. Gelfand, MD, MAS, FAAN

Disclosures

12/1/14I recently attended a trial investigator meeting as a sub-investigator for a clinical trial sponsored by Medimmune.

Jeffrey M. Gelfand, MD, MAS, FAAN

Disclosures

12/1/14I recently attended a trial investigator meeting as a sub-investigator for a clinical trial sponsored by Medimmune.

Autoimmune GFAP Astrocytopathy Associated with Meningitis, Encephalitis, and Myelitis

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Reviewing Author