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In utero infection with Toxoplasma gondii can result in significant fetal morbidity and sometimes death. Although the seroprevalence of toxoplasma infections in women of childbearing age in the U.S. has declined (from 15% during 1988–1994 to 9% during 1999–2004), consequences of maternal infection include hydrocephalus, sensorineural hearing loss, and developmental delay. Diagnosis and management of both pregnant women who may be infected and their infants is complex. In the current technical report, the authors summarize current evidence from observational studies on the epidemiology, diagnosis, treatment, and prevention of T. gondii infection.
Key points include the following:
Maternal to fetal transmission risk increases throughout gestati…