What Mild Cognitive Impairment Might Mean in Parkinson Patients

Rates of MCI increased during a 5-year study, and persistent MCI was associated with increased dementia risk.

To examine mild cognitive impairment (MCI) in Parkinson disease (PD), investigators followed up on an incident population of patients newly diagnosed with PD who underwent neuropsychological testing over a 5-year period. The authors classified MCI dementia using the Movement Disorders Society level one criteria in the domains of attention, executive function, memory, and visuospatial ability.

Twenty percent of 178 patients met MCI criteria at the first neuropsychological examination. The incidence of MCI was 10% at year 1, 23% at year 3, and 29% at year 5. Among those with MCI diagnosed at baseline or during the 5-year follow-up, 39% progressed to dementia. Among those with MCI at both baseline and 1-year exam, 59% later converted to dementi…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)