Rebleeding Risk Is Lower in Oozing Peptic Ulcers

The risk for rebleeding from peptic ulcers can be predicted by the presence of endoscopic stigmata of recent hemorrhage (SRH) as defined by the Forrest classification. SRH are used as indications for endoscopic therapy and intravenous proton pump inhibitor (PPI) treatment. Forrest I (FI) lesions (active bleeding) have the highest rebleeding risk but whether the risk differs between spurting lesions (FIA) versus oozing lesions (FIB) is unclear.

Investigators performed a post hoc analysis of data from a large, randomized trial comparing rebleeding after high-dose PPI treatment versus placebo after successful endoscopic therapy. Among the placebo group (388 patients), the 72-hour rebleeding rates stratified by baseline endoscopic classification…