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To better characterize the course of Tourette syndrome, investigators in Denmark annually examined changes in symptoms during a 6-year follow-up. Participants were 314 patients with Tourette syndrome who were recruited from a tertiary care clinic (mean age, 12 years; range, 5–20 years; 18% female).
The 6-year follow-up involved 227 patients (72%; mean age, 19). Tics decreased significantly during each year of follow-up. By the end of follow-up, 18% of patients age >16 had no tics, 60% had mild or moderate tics, and 23% had severe tics. Of participants with persistent tics, 56% had comorbidities, most typically attention-deficit/hyperactivity disorder (ADHD) or obsessive-compulsive disorder (OCD). ADHD occurred in 41% at baseline and in 33% a…