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Fecal microbiota transplantation (FMT) has been proposed for the treatment of ulcerative colitis. Of the two randomized, controlled trials of single-donor FMT (at a maximum once-weekly frequency) that have been performed in patients with ulcerative colitis, one study showed a possible improved outcome.
In the current double-blind study, researchers utilized a protocol of intensive FMT from multiple donors, randomizing 85 patients to FMT or placebo delivered via an initial colonoscopy and then by enema on at least 5 out of 7 days per week for 8 consecutive weeks. At least 3 to 7 individual donors contributed to each batch of FMT material. Participants were allowed to be on medications other than enema therapy prior to the trial if their doses…