Seizures in the setting of encephalitis and, sometimes, optic neuritis, could have an immunologic origin.
Presence of myelin oligodendryocyte glycoprotein (MOG) antibodies has been associated with a neuromyelitis optica spectrum disease phenotype. Investigators identified an individual who initially presented with isolated optic neuritis. Seven months later the patient had a generalized seizure, subtle unilateral hemispheric cortical hyperintensities on T2-weighted magnetic resonance imaging (MRI), mild cerebrospinal fluid (CSF) pleocytosis, and anti-MOG seropositivity. Based on this index case, 24 patients with steroid-responsive encephalitis over a 6-year period at a single institution were reviewed; 3 more cases were identified.
All 4 cases were men (age range, 23–39) with unilateral hemispheric cortical changes on T2-weighted brain MRI at en…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)