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Acute fatty liver disease of pregnancy (AFLP) is an uncommon but serious obstetrical emergency, usually occurring during the third trimester. The current review covering etiology, diagnosis, clinical outcomes, and management of AFLP includes these key take-home points:
Fetal fatty acid oxidation defects (FAODs), which are deficiencies of enzymes related to mitochondrial metabolism of fatty acids (e.g., fetal long-chain 3-hydroxyacyl-CoA dehydrogenase), are probable risk factors for AFLP.
Established risk factors include multigravida state, male sex of fetus, previous AFLP episode, and co-occurrence of another liver disease during pregnancy (e.g., preeclampsia).
Worldwide maternal mortality estimates have decreased from nearly 100% to <10% due …