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Multiple population-based studies have suggested an association between the use of proton-pump inhibitors (PPIs) and a host of medical conditions.
To determine whether PPI use is associated with ischemic stroke, investigators used the Taiwan National Insurance Database to propensity match current PPI users with nonuser controls and measured occurrence of first-time ischemic stroke during a 120-day period. Analysis of 198,000 PPI treatment courses and nonuse control periods showed that risk for stroke was higher for PPI users than controls (hazard ratio, 1.36) and that the association was more prominent in patients younger than 60 years of age.
The researchers also performed a nested case-control analysis of more than 15,378 patients hospitali…