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Exclusive breast-feeding induces ovarian quiescence and decreases estrogen secretion. These changes may contribute to the mechanism linking breast-feeding and lower risk for breast and ovarian cancer. To investigate whether this relation extends to endometrial cancer, investigators pooled individual data from 3 cohort studies and 14 case-control studies including 8981 parous women with endometrial cancer and 17,241 parous controls. In both groups, about two thirds of women reported histories of breast-feeding.
Ever breast-feeding was associated with 11% lower risk for endometrial cancer (pooled odds ratio, 0.89; 95% CI, 0.81–0.98). Although lifetime cumulative breast-feeding of ≤3 months and mean breast-feeding duration of ≤3 months per newb…