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Antiretroviral therapy (ART) has multiple benefits, of which increased lifespan of people living with HIV (PLWH) is perhaps the most profound. Using data from more than 80,000 PLWH in 18 cohorts from Western Europe and North America, investigators in the Antiretroviral Therapy Cohort Collaboration (ART-CC) assessed mortality outcomes in the first 3 years of ART based on calendar year of ART initiation, and used these data to estimate trends in life expectancy.
Overall, persons starting ART in the most recent years (2008–2010) had significant declines in all-cause mortality during the first 3 years of ART compared with those starting ART between 1996 and 2007. PLWH who inject drugs or who initiated ART at CD4 counts <100 cells/µL did not show…