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Documentation of drug-induced autoimmune hepatitis (DIAIH), a type of drug-induced liver injury (DILI), is increasing. To investigate its natural history, response to corticosteroids, and the risk for relapse after therapy discontinuation, researchers in Iceland evaluated 15 patients identified from their previous cohort studies whose conditions fulfilled the definition of DIAIH. Results were as follows:
The likelihood of the exposure drug (infliximab in 11 patients, nitrofurantoin in 3, imatinib in 1) causing the injury was highly probable in one case, probable in 12, and possible in 2.
Six patients had at least probable autoimmune hepatitis (AIH).
Hepatocellular injury pattern was present in most (93%), jaundice in 53%, and coagulopathy in n…