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Restless legs syndrome (RLS) is associated with an urge to move the legs at night that is worse at rest and better with movement. To assess the placebo and nocebo responses in RLS, researchers reviewed data on 5046 participants (average age, 54 years; 62% female) from 85 randomized, double-blind, placebo-controlled trials. Most studies included patients with idiopathic RLS. Ropinirole, pramipexole, rotigotine, and gabapentin-enacarbil were the most common active treatments assessed in the included studies.
The primary outcome was change from baseline RLS severity or disability; secondary outcomes included self-reported measures of clinical improvement, daytime sleepiness, and quality of life and objective measures such as the periodic limb m…