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Parents of children with autism spectrum disorder (ASD), especially when children have moderate-to-severe language and social impairments, frequently seek nutritional and dietary approaches. This review, commissioned by the Agency for Healthcare Research and Quality, covered the literature from January 2010 to September 2016.
A systematic literature search yielded close to 6600 publications; 19 randomized, controlled studies, each with ≥10 participants, met inclusion criteria (N=732). Dietary approaches included supplementation with digestive enzymes, vitamin B12, and omega-3 fatty acids, as well as diets free of dairy, gluten, and gluten/casein. Analyses examined outcome, bias, and strength of evidence in the studies. Overall, all publicati…