Risk for Metachronous Lesions Is Lower in Younger People

To examine the risk for metachronous neoplasia and advanced neoplasia after polyp resection in young people compared with older people, researchers at a single center compared outcomes at follow-up colonoscopy between 128 patients younger than 40 years old (mean age, 35) and 123 patients aged >50 years (mean age, 58).

Among the younger group, 97% had adenomas and 7% had serrated sessile polyps (SSPs) at baseline, and 35% had advanced neoplasia at baseline (SSP with dysplasia, traditional serrated adenoma, adenoma of the villous component, high-grade dysplasia, or cancer). Patients with known inherited colon cancer syndromes were excluded. All patients had at least one follow-up at the center.

Median time to follow-up colonoscopy was 34 months…