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Uncomplicated soft-tissue abscesses are seen commonly in U.S. emergency rooms and urgent care centers, particularly since emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA). Researchers have performed a multicenter, double-blind trial of 786 outpatients (505 adults, 281 children) with small skin abscesses (<5 cm; smaller size criteria for pediatric patients). Participants were randomized to incision and drainage plus either clindamycin (300 mg every 8 hours), trimethoprim-sulfamethoxazole (TMP/SMX; 160 mg TMP/800 mg SMX every 12 hours), or placebo (with dose adjustments in pediatric patients).
In the intent-to-treat (ITT) analysis, clinical cure rates at the test-of-cure visit were 83% after clindamycin, 82%…