CT Perfusion Predicts Response to Reperfusion Therapy for Acute Ischemic Stroke

Imaging-based patient selection will be key to extending the time window for endovascular stroke therapy.

For both intravenous thrombolysis and endovascular stroke treatment, the average efficacy of the intervention gradually decreases as the time from symptom onset increases. But for an individual patient, an irreversible core infarct can set in within minutes or ample collateral flow may be available to sustain ischemic tissue over hours. Imaging-based criteria to distinguish core infarct from salvageable penumbra could help to select individual patients for reperfusion therapy irrespective of time.

The NIH-sponsored CRISP (CT Perfusion to Predict Response to Recanalization in Ischemic Stroke Project) study tested this theory. Researchers enrolled 201 consecutive patients with anterior circulation stroke who were scheduled for endovascular the…

Reviewing Author

Anthony S. Kim, MD

Disclosures

Grant/Research SupportNIH/National Institute of Neurological Disorders and Stroke; NIH/National Center for Advancing Translational Sciences

Anthony S. Kim, MD

Disclosures

Grant/Research SupportNIH/National Institute of Neurological Disorders and Stroke; NIH/National Center for Advancing Translational Sciences

CT Perfusion Predicts Response to Reperfusion Therapy for Acute Ischemic Stroke

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Reviewing Author