Concurrent HPV testing in women with atypical squamous cells of undetermined significance identified more of those with high-grade dysplasia, but overtreatment was still common.
The effect of human papillomavirus (HPV) cotesting in conjunction with cytological cervical screening remains unclear. Investigators in New Mexico (where all Pap results are linked to pathology reports) examined the outcomes of women whose initial cervical screening showed atypical squamous cells of undetermined significance (ASC-US) cytology with or without HPV testing.
About 4.5% of the 457,000 women screened between 2008 and 2012 had ASC-US cytology. Of these, 80% underwent HPV testing concurrently or soon thereafter. During follow up (median, 57 months), 84% of women had normal histology, 10% had cervical intraepithelial neoplasia grade 1 (CIN1), 4% had CIN2, and 2% had CIN3. HPV testing was associated with 15% more likely detection of h…
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)