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Some studies suggest that thromboembolic events are more common after a major bleeding episode. To see if there is an association between gastrointestinal bleeding (GIB) and subsequent thromboembolic events, investigators in Japan retrospectively reviewed data from the endoscopic database of a single institution and identified 522 patients with GIB and 1044 matched controls without bleeding who also underwent endoscopy.
At a mean follow-up of 23.7 months, thromboembolic events occurred more often in GIB patients than controls (11.5% vs. 2.4%; P<0.001). Multivariate analysis suggested that GIB is associated with all thrombotic events, cerebrovascular events, and cardiovascular events. Mortality was also higher in the GIB group (15.9% vs. 8.6%…