Longer-Term Follow-up from a Prostate Cancer Trial

In the PIVOT trial, mortality reduction with radical prostatectomy failed to achieve statistical significance.

In 2012, researchers published results of the PIVOT (Prostate Cancer Intervention versus Observation Trial) randomized trial, in which 731 men with largely PSA-detected localized prostate cancer received radical prostatectomy or observation. At median follow-up of 10 years, surgery did not significantly lower overall or prostate cancer–specific mortality (NEJM JW Gen Med Aug 15 2012 and N Engl J Med 2012; 367:203). Now we have longer-term follow-up.

During up to 20 years of follow-up (median follow-up, 13 years), overall mortality was 61.3% with surgery and 66.8% with observation (P=0.06); for prostate cancer–specific mortality, these figures were 7.4% vs. 11.4% (again, P=0.06). As in the 2012 report, subgroup analyses suggested trends towar…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Longer-Term Follow-up from a Prostate Cancer Trial

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Reviewing Author