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Tissue transglutaminase (tTG) immunoglobulin A (IgA) antibody is a serologic marker for celiac disease that is recommended for use in both diagnosis and follow-up. To determine if undetectable levels (<1.2 U/mL) of tTG IgA carry a different prognosis compared with normal but detectable levels (1.2–4.0 U/mL), investigators retrospectively assessed mucosal healing in 402 patients with celiac disease who had a tTG IgA level <4 U/L determined within 1 month of a small bowel biopsy. All patients had followed a strict gluten-free diet for at least 6 months and had no immunoglobulin deficiency. Results were as follows:
Patients with undetectable tTG IgA levels were twice as likely to have normal villous architecture compared with patients with norm…