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In the landmark SPRINT study, nondiabetic hypertensive patients at high risk for adverse cardiovascular (CV) outcomes were treated to achieve intensive or standard systolic blood pressure (BP) targets (<120 vs. <140 mm Hg). During average follow-up of 3.3 years, a composite adverse CV outcome occurred significantly less frequently in the intensively treated group (5.2% vs. 6.8%; NEJM JW Gen Med Dec 15 2015 and N Engl J Med 2015; 373:2174). But two important questions remain: First, because side effects of BP medications can affect general well-being, did intensive treatment have an adverse effect on quality of life, compared with standard treatment? And second, because about 60 people had to be treated intensively to prevent one adverse CV …