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Sleep disruption has been associated with Alzheimer disease pathology, and slow-wave sleep may be a key factor in amyloid and tau dynamics. These researchers investigated whether slow-wave sleep disruption affected cerebrospinal fluid (CSF) amyloid and tau levels in 17 cognitively normal healthy individuals.
Participants aged 35 to 65 years underwent wrist actigraphy for 5 to 14 days to estimate sleep duration and quality, then had an overnight polysomnography during which slow-wave activity was disrupted by an auditory stimulus in the experimental condition and uninterrupted in the sham condition. Polysomnography was followed by a morning lumbar puncture to assess for amyloid-β, tau, total protein, YKL-40 (a neuroinflammatory protein), and …