Associations of Nutrient Intake with Cardiovascular Disease and Total Mortality: Insights from PURE

Data from PURE, a large global epidemiology study, might turn diet dogma on its head.

How are nutrients linked to cardiovascular disease risk markers and outcomes, and do the associations differ around the world? To find out, researchers in the Prospective Urban Rural Epidemiology (PURE) study enrolled 157,543 men and women from 667 communities in 18 countries (from all income levels) and used food-frequency questionnaires to determine participants' usual intakes of specific foods (NCT03225586). They have now reported results in a series of articles.

In one report, the investigators used multilevel modelling to predict the effects of replacing saturated fat with other fats or with carbohydrates. They found that replacing saturated fat with carbohydrates would be associated with the worst effects on blood lipids, whereas repla…

Reviewing Author

Karol E. Watson, MD, PhD, FACC

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)