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In 2010, Pittock and colleagues described a condition that they termed chronic lymphocytic inflammation with perivascular enhancement responsive to steroids (CLIPPERS). Clinical symptoms are related to brainstem involvement and include gait ataxia and diplopia. Other symptoms observed are dysarthria, altered sensation and paresthesia of the face, dizziness, nystagmus, spastic paraparesis, and pseudobulbar affect. The radiologic distribution is particularly focused in the pons and adjacent rhombencephalic structures such as cerebellar peduncles, cerebellum, medulla, and midbrain.
The lack of formalized diagnostic criteria for this syndrome has led to reports in the literature that often don't correspond to the disease. In this study, the auth…