Loading...
Gabapentinoids (gabapentin and pregabalin [Lyrica]) often are prescribed off-label for various pain syndromes, including low back pain. In this systematic review and meta-analysis, researchers identified eight randomized, controlled trials of gabapentinoids for chronic low back pain. Treatment duration ranged from 3 to 14 weeks. The following results were noted:
In three studies (185 patients total), gabapentin was compared with placebo. Pain relief was not significantly better with gabapentin than with placebo. Dizziness, fatigue, visual disturbances, and “difficulty with mentation” were significantly more common with gabapentin.
In three studies (332 patients total), pregabalin was compared with another analgesic (i.e., tramadol, amitriptyl…