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Aspirin is a mainstay in the treatment of patients with coronary artery disease and has been used for primary prevention. To learn about the effect of discontinuing aspirin, investigators examined Swedish national databases to conduct a partially industry-funded, cohort study of approximately 600,000 users of low-dose aspirin for primary or secondary prevention between 2005 and 2009.
Included were people aged >40, without cancer histories, and with an 80% adherence during the first year of aspirin use (mean age, 73; 52% women; diabetes, 16%); 54% used aspirin for secondary prevention, whereas the others likely used aspirin as primary prevention. Almost 63,000 cardiovascular events occurred during a median follow-up of 3 years (incidence rate…