Single vs. Double-Active Antimicrobial Therapy in Patients with Septic Shock

Mortality was generally similar for single and double-active therapy, but neutropenic patients and those infected with P. aeruginosa had better outcomes with double-active therapy.

Current sepsis treatment guidelines recommend combination antibiotic therapy for patients with septic shock, but evidence supporting this recommendation is scarce. Now, a retrospective study involving 576 patients treated for monomicrobial septic shock between January 2010 and December 2015 at a single institution sheds some light on this issue. Of the patients, 340 (59%) received empirical active antibiotic monotherapy (AM) and 236 empirical double-active combination therapy (DACT). Patients receiving DACT were younger, received corticosteroids more often, and were more likely to have a nonfatal underlying disease, hematologic malignancy, or neutropenia, whereas patients receiving AM more often had solid-organ malignancies, prior surgery, …

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Single vs. Double-Active Antimicrobial Therapy in Patients with Septic Shock

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Reviewing Author