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Natural orifice transluminal endoscopic surgery (NOTES) was once a red-hot area of study, offering the promise of incisionless endoscopic surgery as an alternative to standard laparotomy or laparoscopic surgery. While in great part NOTES has not lived up to its potential, some topics have been investigated in detail, such as NOTES cholecystectomy (by the transgastric or transvaginal route).
In a recent single-center study, researchers compared postoperative pain and adverse events between 226 female patients undergoing laparoscopic cholecystectomy (LC) and 90 undergoing NOTES transvaginal cholecystectomy (TVC) for treatment of symptomatic cholelithiasis. Patients selected the procedure of their choice, and all procedures were performed by on…