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In the U.S., detectable concentrations of pesticides or their metabolites are present in most individuals, primarily through eating conventionally grown fruits and vegetables (FVs) — but the effects on reproductive outcomes remain unknown. Using a validated questionnaire to estimate dietary exposure to pesticide residues, researchers investigated the associations between preconception intake of high- and low-pesticide residue FVs and reproductive outcomes in a prospective cohort of 325 women undergoing 541 in vitro fertilization (IVF) cycles.
In all, 228 cycles (42%) resulted in live birth. High-pesticide FV intake was inversely associated with probability of clinical pregnancy and live birth per IVF cycle: Compared with women in the lowest …