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Helicobacter pylori infection is a known risk factor for gastric cancer (GC). Eradication of the infection may reverse some GC precursor states, such as gastric mucosal atrophy and intestinal metaplasia, but will it reduce the incidence of metachronous GC?
To find out, investigators in Korea retrospectively reviewed 565 patients from a single center who underwent endoscopic resection of early GC. Follow-up endoscopy was performed at 3, 6, and 12 months after resection, and annually thereafter.
At median follow-up of ≥60 months, 157 patients were negative for H. pylori infection at the time of resection, 212 underwent successful H. pylori eradication after resection, and 196 had persistent H. pylori infection after resection. Antral mucosal at…