Troponin elevations above the 99th percentile on high-sensitivity testing often represent type 2 infarction or myocardial injury without infarction.
High-sensitivity troponin (hsTn) testing has been widely available in the UK and Europe for years and was recently approved for clinical use in the U.S. Troponin elevation can result from type 1 myocardial infarction (MI; plaque rupture), type 2 MI (demand ischemia), or myocardial injury without evidence of infarction.
In a prospective observational study, researchers determined the positive predictive value (PPV) of elevated hsTnI for type 1 MI in three cohorts of consecutive emergency department (ED) patients: an unselected UK cohort of 1054 patients who had blood drawn for any reason, a selected cohort of 5815 UK patients whose clinicians ordered troponin testing for suspected acute coronary syndrome (ACS), and a selected cohort of 1631 U…
Reviewing Author
DisclosuresRoyaltiesUpToDate
Grant/Research SupportEunice Kennedy Shriver National Institute of Child Health and Human Development; MINDSOURCE
Editorial BoardsThe Quarterly Update: Reviews of Current Child Abuse Medical Research; Child Abuse & Neglect: The International Journal
Leadership Positions in Professional SocietiesThe Helfer Society (Executive Committee Member)
DisclosuresRoyaltiesUpToDate
Grant/Research SupportEunice Kennedy Shriver National Institute of Child Health and Human Development; MINDSOURCE
Editorial BoardsThe Quarterly Update: Reviews of Current Child Abuse Medical Research; Child Abuse & Neglect: The International Journal
Leadership Positions in Professional SocietiesThe Helfer Society (Executive Committee Member)