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Investigators describe clinical and prognostic features for 252 patients in the U.K. with a neurologic syndrome who test positive for myelin oligodendrocyte glycoprotein (MOG) antibodies, including 75 patients from Oxford with more-detailed data.
Phenotype had three peak onset-age distributions. Those younger than 20 years often presented with acute disseminated encephalomyelitis (ADEM) and proportionally had less monofocal optic neuritis (ON) and transverse myelitis (TM). Those aged 20–45 years were most likely to present with simultaneous ON and TM. Those aged >45 years most often had either TM or ON. Some patients presented with a neuromyelitis optica–like phenotype; others had unilateral ON or short-segment TM. Recovery from the first ep…