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No consistently effective pharmacotherapy exists for preventing relapse in cocaine use disorder. However, sertraline has shown promise in abstinent individuals with some depression symptoms. The current researchers pooled data from two similarly designed, 12-week, double-blind studies in Connecticut and Arkansas (N=126; median age, 39).
All participants were cocaine dependent, were randomized as inpatients to sertraline at 200 mg/day or placebo, and completed 2 weeks of residential treatment. Rates of current major depression were 74% in the Connecticut study and 50% in the Arkansas study. In both treatment groups, current alcohol dependence diagnosis, older age, male sex, lower depression ratings, and a negative urine screen at baseline pre…