New Sepsis Criteria for Pneumonia Mortality: Is SIRS Out and qSOFA and CRB In?

In a large retrospective study comparing various measures of sepsis and pneumonia severity, the qSOFA and CRB scales outperformed the previously used SIRS in predicting hospital mortality.

In 2016, the Sepsis-3 Task Force updated their recommendations and removed the systemic inflammatory response system (SIRS) criteria. Instead, sepsis was defined by an increase by ≥2 points in the sequential (sepsis-related) organ failure assessment (SOFA) tool. The task force introduced a Sepsis-3 flowsheet that employs the quick SOFA (qSOFA), which uses respiratory rate, blood pressure, and mental status to generate a score.

To ascertain the usefulness of this newer system in the management of community-acquired pneumonia (CAP), investigators analyzed two adult cohorts totaling 6874 patients, using SIRS, qSOFA, and three assessments of CAP severity: the Confusion, Urea, Respiratory Rate, Blood Pressure, and Age (CURB-65) score; CRB (a nonl…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

New Sepsis Criteria for Pneumonia Mortality: Is SIRS Out and qSOFA and CRB In?

Topics

Reviewing Author