Increasing Intraosteoblastic Activity of Daptomycin with Beta-Lactams

The persistence of Staphylococcus aureus within osteoblasts suggests that therapies having intracellular activity may reduce relapses. The potent antistaphylococcal activity of daptomycin has resulted in its being increasingly used to treat osteomyelitis and septic arthritis. However, the intracellular activity of daptomycin alone is relatively weak, prompting investigation of ways to increase it through combination therapy.

Daptomycin's activity is enhanced by beta-lactams, thus these authors examined the effects of oxacillin and ceftaroline on daptomycin against both methicillin-resistant and methicillin-susceptible S. aureus (MRSA and MSSA, respectively) in osteoblasts using drug concentrations achieved in bone with standard dosing. Dapto…