Limitations of PrEP Guidelines in Identifying Young Black Men Who Have Sex with Men at High Risk for HIV Seroconversion

Current guidelines performed relatively poorly among young black MSM, emphasizing the need for better approaches to determine eligibility for PrEP.

Pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition is highly effective with proper use. Guidance for clinicians to identify those who may benefit from PrEP include the CDC PrEP guidelines for men who have sex with men (MSM), the HIV Incidence Risk Index for MSM (HIRI-MSM), and the Gilead package insert for Truvada. (The HIRI-MSM guideline generates a score based on additional demographic and behavioral factors, while the Gilead guidelines incorporate the prevalence of HIV in social networks or in the community.) Using these guidelines, investigators retrospectively evaluated individual risk at the time of enrollment into uConnect, a longitudinal cohort of young black MSM in Chicago. HIV serostatus was determined at subsequent…

Reviewing Author

Wendy S. Armstrong, MD

Disclosures

Consultant/Advisory BoardNIH Therapeutics and Prevention Data Safety Monitoring Board

Leadership Positions in Professional SocietiesAmerican Board of Internal Medicine Infectious Diseases Subspecialty Board (member), Infectious Diseases Society of America (Vice President)

Wendy S. Armstrong, MD

Disclosures

Consultant/Advisory BoardNIH Therapeutics and Prevention Data Safety Monitoring Board

Leadership Positions in Professional SocietiesAmerican Board of Internal Medicine Infectious Diseases Subspecialty Board (member), Infectious Diseases Society of America (Vice President)

Limitations of PrEP Guidelines in Identifying Young Black Men Who Have Sex with Men at High Risk for HIV Seroconversion

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Reviewing Author