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Many liver diseases differ in prevalence and outcomes based on gender, with women having a higher burden; however, little is known regarding gender differences in acetaminophen-induced acute liver injury or failure.
Using prospectively collected data from a U.S. registry, researchers analyzed gender differences in presentation and clinical course of acetaminophen-induced acute liver injuries (250 cases) and failures (912 cases). Patients were treated at one of 32 academic medical centers between 2000 and 2016.
The majority of acetaminophen-induced injuries (68%) and failures (76%) were in women, who had a higher prevalence of psychiatric illness (60% vs. 48%) and coingestion of acetaminophen with sedating medications (70% vs. 52%) compared wi…