Protease Inhibitors Associated with Worse Outcomes After Kidney Transplantation

Additional reasons to avoid PIs after renal transplantation in HIV-positive recipients.

Kidney disease is common in human immunodeficiency virus (HIV)–infected patients, and kidney transplantation is now widely accepted as the favored treatment for end-stage renal disease in most persons with well-controlled HIV infection. Absent hepatitis C coinfection, outcomes are similar in these patients and HIV-negative recipients (J Am Soc Nephrol 2015; 26:2222). Nonetheless, challenges remain, including drug interactions, optimal selection of induction immunosuppressive agents, and increased rates of rejection.

To determine the association between antiretroviral treatment regimens and graft and patient survival, researchers linked data from the Scientific Registry of Transplant Recipients with prescription fill data. They included 332 H…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Protease Inhibitors Associated with Worse Outcomes After Kidney Transplantation

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Reviewing Author