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Alternatives to liver transplantation are needed to treat decompensated cirrhosis. Given recent evidence that granulocyte colony-stimulating factor (G-CSF) might be effective for alcoholic hepatitis, researchers in India evaluated its effect on 12-month transplant-free survival among 65 patients receiving treatment for decompensated cirrhosis at a single tertiary center.
Patients were randomized to standard medical therapy plus G-CSF (1 course every 3 months) plus growth hormone (daily), standard medical therapy plus G-CSF, or standard medical therapy alone for 12 months.
The groups taking G-CSF had significantly lower mortality risk (hazard ratio in group taking growth hormone, 0.16; without growth hormone, 0.09) compared with those receivin…