Accurate Tool for Predicting Time to End-Stage Renal Disease in Pediatric CKD

The kidney failure risk equation, developed for adults, was also accurate in children with stage 3 or 4 chronic kidney disease.

Although risk factors for progression of chronic kidney disease (CKD) in children are known, we lack a model for predicting the time to end-stage renal disease (ESRD) when renal replacement therapy is required.

In a retrospective cohort study, researchers assessed the accuracy of the four-variable and eight-variable kidney failure risk equations (KFREs; previously validated in adults) in predicting 1-year, 2-year, and 5-year risks for progression to ESRD in 603 children (median age, 12 years) with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m² (median, 44/mL/min/1.73m²). The four-variable model uses eGFR, age, sex, and albumin-to-creatinine ratio; the eight-variable model adds serum calcium, phosphate, bicarbonate, and albumin…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Accurate Tool for Predicting Time to End-Stage Renal Disease in Pediatric CKD

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Reviewing Author