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Time is of the essence for acute stroke interventions, but time to treatment remains a fairly coarse predictor of prognosis or response to therapy. Some patients will go on to have large infarcts, even when treated very early on, and others may still have viable penumbra to save when treated many hours after symptom onset. Therefore, developing a more individualized assessment of tissue viability and response to therapy that is independent of time would be quite useful.
Now, investigators have conducted a single-center cohort study involving 355 consecutive patients with internal carotid or proximal middle cerebral artery occlusion who had whole-brain perfusion computed tomography (CT) with CT angiography performed within 6 hours of stroke o…