In a placebo-controlled trial, anticholinergic agents improved both urgency urinary incontinence and sleep quality.
Poor-quality sleep and urgency urinary incontinence (UUI) are common complaints in postmenopausal women. To test whether pharmacologic therapy with an antimuscarinic agent to manage UUI also improves sleep quality, investigators conducted a planned secondary analysis of a manufacturer-sponsored 12-week trial of fesoterodine to reduce urgency urinary incontinence. In all, 645 community-dwelling women (mean age, 56; 79% in self-reported excellent health) were randomized to fesoterodine or placebo.
While both groups experienced reductions from baseline in incontinence, women who received fesoterodine had statistically significantly greater reductions in total and urgency incontinence as well as number of nocturnal voids. Measures of sleep quali…
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)