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Acute influenza infection has long been a suspected risk factor for acute myocardial infarction (MI), but studies supporting this association have had limitations.
Investigators have now performed a self-controlled case-series study to definitively assess the incidence of hospitalizations for acute MI among patients presenting with influenza in Ontario, Canada, between 2008 and 2015. Influenza cases were confirmed by high specificity molecular, culture, or enzyme immunoassays during either a risk interval (7 days following a positive influenza test) or a control interval (1 year before and 1 year after the influenza test result, excluding the risk interval).
During the 7-year study period, 364 hospitalizations for acute MI occurred in 332 pat…