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The most common causes of acute kidney injury (AKI) in patients with cirrhosis are hepatorenal syndrome type 1 (HRS), acute tubular necrosis (ATN), and prerenal azotemia (PRA). Early identification of the cause of AKI is essential to direct early intervention to prevent further deterioration of renal function.
In a retrospective, single-center study, researchers evaluated the utility of fractional excretion of urea (FEUrea) in differentiating causes of AKI in patients with cirrhosis and ascites admitted with AKI. The reference standard for etiology of AKI was adjudication by a hepatologist and nephrologist using validated criteria. FEUrea was calculated as follows: [(spot urine urea/admission serum urea)/(spot urine creatinine/admission seru…